Since the autophagy process is proven to be active in the TBI process (Clark et al., 2008; Wu and Lipinski, 2019; Zeng et al., 2020; Lang et al., 2024), the present study investigates the use of LC3B, Beclin 1, p62, and LAMP2A as a forensic diagnostic marker for brain trauma. The gene discussed is SQSTM1; the disease is brain injury.