GPER1 and COVID-19: Clinical data indicate that men, following SARS-CoV-2 infection, tend to experience higher levels of hospitalization and mortality from COVID-19 compared to women; the involvement of GPER in this disparity has been suggested, since its activation, demonstrated in experimental models, reduces the viral load of SARS-CoV-2 in bronchial cells infected with SARS-CoV-2 (42).