In CCC, TGF-β has increased expression and has been correlated to a poor prognosis (Araújo-Jorge et al., 2002; Ferreira et al., 2019), such as cardiac dysfunction, arrhythmias, ventricular dilation, increased risk of HF, and sudden death (Rassi et al., 2010). This evidence concerns the gene TGFB1 and hydrops fetalis.