AGT and Hypertension: Testosterone-CYP1B1-generated metabolite 6β-hydroxytestosterone, most likely in the PVN via androgen receptor and G protein-coupled receptor C6A, elicited an increased reactive oxygen species (ROS) production, activation of microglia and astrocyte, and elevated neuroinflammation, contributing to ANG II-induced hypertension in male mice (Singh et al., 2020a).