They also found that there are age- and sex-specific differences in the enhancing effects of these two prenatal conditions on postnatal angiotensin receptor expression (AT1R and AT2R) in the kidney, suggesting that upregulation of the RAS plays an important role in the pathogenesis of programmed hypertension through receptor-mediated changes in ANG II activity (McMullen and Langley-Evans, 2005). This evidence concerns the gene AGT and hypertensive disorder.