AGT and hypertensive disorder: Thereafter, we have used a prenatal insult model to investigate the pathogenesis of hypertension in offspring; we demonstrated similar sensitizing effects of maternal gestational hypertension on the development of hypertension in offspring when they are challenged as adults (10 weeks of age) with ANG II or a high fat diet (HFD), as “second hits” (Xue et al., 2017; Xue et al., 2021; Xue et al., 2022a).