BFR-LI training also facilitates fibrinolysis by increasing tissue plasminogen activator (t-PA), reducing plasminogen activator inhibitor-1 (PAI-1), and activating the fibrinolytic system, thereby lowering the risk of thrombosis (Landers et al., 2025); on the other hand, it may increase the risk of thrombosis due to blood stasis, endothelial injury, and hypercoagulability (Engbers et al., 2010). The gene discussed is SERPINE1; the disease is thrombophilia.