AFP and neoplasm: In univariate analysis, the risk factors in older patients included BCLC (HR: 1.778, 95% CI: 1.121-2.819, P = 0.014), portal vein tumor thrombus(HR: 1.990, 95% CI: 1.334-2.967, P = 0.001), cerebrovascular disease (HR: 0.480, 95% CI: 0.232-0.991, P = 0.047), previous surgical treatment(HR: 0.424, 95% CI: 0.219-0.821, P = 0.011), elevated glutamic oxaloacetic transaminase (AST) (HR: 1.007, 95% CI: 1.002-1.011, P = 0.003), and AFP ≥ 400 ng/mL (HR: 1.774, 95% CI: 1.194-2.637, P = 0.005).