However, in some atypical HNPCC —— hereditary type 7 colorectal cancer, MLH3 germline mutations show some correlation with it, with clinical manifestations of early-onset colorectal cancer or multiple primary tumors, but with a lower rate of outgrowth than MLH1 or MSH2 mutations (6). The gene discussed is MSH2; the disease is hereditary nonpolyposis colon cancer.