TXNIP and type 2 diabetes mellitus: In one study investigating the incidence of T2D in people of Indian Asian ancestry (discovery cohort; 1,074 with T2D and 1,590 without T2D) and people of European ancestry (replication cohort; 377 with T2D and 764 without T2D), five CpG sites (TXNIP, ABCG1, PHOSPHO1, SOCS3, and SREBF1) were identified by Illumina 450 K microarray as having a statistically significant association with T2D after replication (Table 1) (Chambers et al., 2015).