In a study of liver tissue using the Illumina 450 K Beadchip, significant hypomethylation at a CpG site within PDGFA was identified in a European ancestry cohort of 96 women with obesity and T2D (mean age: 48.2 years with SD ± 6.34 years) and 96 age and BMI matched women with obesity and without T2D (41.3% methylation for participants with T2D versus 60.3% methylation for participants without T2D) (Abderrahmani et al., 2018). The gene discussed is PDGFA; the disease is obesity due to melanocortin 4 receptor deficiency.