Further, a meta-analysis of European ancestry populations (340 with T2D and 3,428 without T2D; Illumina 450 K Beadchip) revealed 6 CpG sites (TXNIP, ABCG1, CPT1A, HDAC4, SYNM, and MIR23A) as well as 77 differentially methylated regions that were associated with T2D (Juvinao-Quintero et al., 2021). This evidence concerns the gene SYNM and type 2 diabetes mellitus.