As shown in Figure 4, the clusters arranged from top to bottom are #0 high blood pressure, #1 diabetes mellitus, #2 metabolic syndrome, #3 blood pressure, #4 receptor blocker, #5 vascular risk factor, #6 current evidence, #7 public health, #8 targeting renin-angiotensin system, #9 subcortical small-vessel disease, #10 angiotensin receptor blocker, #11 non-ad dementia, #12 microvascular injury, #13 dietary pattern, #14 cell, #15 subcortical ischemic vascular dementia and #16 non-genetic factor. The gene discussed is REN; the disease is metabolic syndrome.