This decoction can inactivate the BMP-2/RUNX2/Osterix signal pathway, thereby alleviating inflammatory infiltration, adenine crystal deposition, renal interstitial fibrosis, and calcified nodes in the renal aorta in chronic renal failure rats (Liu et al., 2016), which emphasizes the applicability of traditional Chinese medicine in contemporary therapy and the vital role of RUNX2. The gene discussed is RUNX2; the disease is chronic kidney disease.