In essence, the balance between the pro-phagocytic signal CALR and the anti-phagocytic signal CD47 on tumor cells is critical for the ability of DCs to recognize and phagocytose tumor cells, determining effective antigen cross-presentation and activation of a robust antitumor immune response during radiotherapy (Preet Kaur et al., 2023). The gene discussed is CALR; the disease is neoplasm.