Immunohistochemical analysis of pre-treatment tumor biopsies from 73 HNSCC patients receiving radical chemoradiotherapy revealed that mitochondrial-rich (COX5B) metabolism correlated with higher intra-tumoral CD8/CD4 ratios, whereas glucose-dependent (GLUT1) metabolism correlated with lower ratios (Krupar et al., 2018). The gene discussed is CD4; the disease is neoplasm.