Activation of T Cells A series of cytokines produced by tumor cells, including TGF-β, IL-6, IL-10, and GM-CSF, can induce MDSCs to produce ROS, which facilitates the expression of FasL and inhibits the expression of Bcl2, thereby inducing apoptosis of activated T Cells (Yadav et al., 2023; Dong, 2021). The gene discussed is FASLG; the disease is neoplasm.