Synthesis of glycosphingolipid, a phospholipid, is critical for successful immune escape in KRAS mutation-driven tumors: the level of glycosphingolipid synthesis correlates with the amount of interferon gamma receptor 1 (IFNGR1) on the surface of cancer cells, and blocking glycosphingolipid synthesis leads to an increase in IFNGR1, making the tumor cells more sensitive to immune responses (Soula et al., 2024). This evidence concerns the gene IFNGR1 and cancer.