SENP1 and hepatocellular carcinoma: For example, in hepatocellular carcinoma, it was found that the upregulation of METTL3 promoted the deposition of m6A modification on LncRNA Tetraspanin 12 (TSPAN12), enhanced the stability of LncRNA, and upregulated the expression of lncRNA TSPAN12, acting as a scaffold, promoting the interaction of EIF3I and SUMO specific peptidase 1 (SENP1), thus activating the Wnt/β-catenin signaling pathway to promote EMT (Li et al., 2024).