NKX2-1 and cancer: Furthermore, the TFs from the inhibitor of differentiation (ID) family, such as ID1 and ID3, along with the homeobox TF NK2 homeobox 1 (NKX2-1), are capable of modulating the TIC phenotype in cancer cells (Ullmann et al., 2018; Winslow et al., 2011; Gupta et al., 2007b).