LCN2 and neoplasm: The ability of LCN2 to promote invasion has been ascribed to the ability of LCN2 to promote epithelial–mesenchymal transition (Ding et al., 2015; Yang et al., 2009) and to promote angiogenesis (Yang et al., 2013), suggesting that LCN2 could be a potential therapeutic target in multiple tumor types (Leng et al., 2009; Miyamoto et al., 2016).