LCN2 and chronic kidney disease: Previous data have demonstrated that, in a model of chronic kidney disease, LCN2 stimulates the recycling of activated EGFR to the cell border (Yammine et al., 2019), leading to increased EGFR activity; importantly, this is independent of LCN2 secretion as an LCN2 mutant that is not secreted can still stimulate the recycling of EGFR.