It encodes for 184aa protein and directly interacts with STAT3, enhancing the phosphorylation of STAT3. This increases the growth and migration of ICC cells. IL‐6/cGGNBP2‐184aa/STAT3 forms a positive feedback loop to sustain constitutive activation of IL‐6/STAT3 signaling. This evidence concerns the gene STAT3 and intrahepatic cholangiocarcinoma.