It positively regulates CC‐chemokine ligand 20 (CCL20) and activates the PI3K‐Akt signaling pathway by acting as miRNA sponge increasing proliferation and EMT. It is also positively associated with colonization of CD68+/CD163+/CD206+ TAMs in tumor microenvironment and facilitates the expression of CD163 in macrophages through the CCL20‐CCR6 axis, inducing TAMs infiltration and M2 polarization. The gene discussed is CD68; the disease is neoplasm.