Li et al. (2009) reported that activation of the MAPK pathway in the human nasopharyngeal carcinoma cell line CNE‐2 and the hepatocellular carcinoma cell line Hep3B could mediate the expression of Beclin1, an important autophagy protein that can abnormally activate autophagy, thus inducing the autophagic death of tumor cells. This evidence concerns the gene BECN1 and neoplasm.