For these studies, the B-cell lymphoblastic leukemia cell line SEM with constitutive expression of OsTIR1(F74G), endogenous CTCF-miniAID-mClover (CTCFAID2), and inducible exogenous HA-tagged wild-type CTCF (CTCFAID2/WT) or RBR deficient CTCF (CTCFAID2/dRBR) were used [11]. This evidence concerns the gene CTCF and precursor B-cell acute lymphoblastic leukemia.