EWSR1 and amyotrophic lateral sclerosis: In addition to FUS and TDP-43, mutations in the LCD of other RBPs related to FTD and ALS, such as EWSR1 (Ewing sarcoma breakpoint region 1), TIA1, TAF15, Ataxin2, hnRNPA1, and hnRNPA2B1, have also been reported to interfere with SG assembly [150].