For instance, 18.5–38.7% of patients with ischemic or non-ischemic heart failure, 25.2–29% with cardiogenic shock, 12.4% with STEMI, and 33% undergoing transcatheter intervention for aortic valve stenosis have been reported to carry CHIP-associated mutations in various cohort studies. The gene discussed is STUB1; the disease is aortic valve stenosis.