In the following section, we situate these findings within the broader context of neurodegenerative disease research, emphasizing consistencies, discrepancies, and conceptual progress.The MR analysis identified 76 plasma proteins with causal links to PDD, including protective (ADAMTS5, ADH1 C) and risk (AGT, CHL1) factors. This evidence concerns the gene ADAMTS5 and neurodegenerative disease.