TARDBP and Parkinson disease: This pathway was influenced by mutations in SNCA, TDP43, and PINK1, which have all been implicated in PD.The immune profile of PDD patients exhibited unique patterns of immune cell composition, with notable changes in the proportion of specific cell types, such as NK cells, monocytes and macrophages M1, which may have critical pathological significance in PDD (Fig. 5, S5).