USP8 may be closely associated with a variety of diseases, including pituitary adrenocorticotropic hormone-secreting adenomas, pituitary-dependent Cushing's disease, esophageal squamous cell carcinoma, hereditary spastic paraplegia, and autosomal recessive spastic paraplegia type 59. The gene discussed is USP8; the disease is autosomal recessive spastic paraplegia type 59.