In contrast to the results observed in QRICH1 KD mice, overexpression of QRICH1 significantly exacerbated TAC-induced pathological cardiac hypertrophy, as evidenced by a significant increase in HW/TL, LVW/TL, and LW/BW ratios, along with an increase in cardiomyocyte cross-sectional area and interstitial fibrosis (Supplementary Fig. 4C-E). Here, QRICH1 is linked to cardiac hypertrophy.