A prime example of SLC regulation is seen in glucose homeostasis, where insulin stimulates the translocation of the glucose transporter SLC2A4 (GLUT4) from intracellular vesicles to the plasma membrane in muscle and fat cells, and its dysregulation may contribute to insulin resistance and type-2 diabetes (Zisman et al, 2000). This evidence concerns the gene SLC2A4 and Insulin resistance.