The percentage of T cells (CD3+), CD4 + and CD8 + was significantly reduced in the CLL EBV + and CLL EBV- groups compared to healthy volunteers (HV), while the highest percentage of CD19 + B lymphocytes was observed in patients with CLL, regardless of EBV status (p < 0.000). This evidence concerns the gene CD8A and B-cell chronic lymphocytic leukemia.