ESR1 and uterine corpus endometrial carcinoma: For example, we identified a putative regulatory element located −9 kb of the ESR1 gene encoding estrogen receptor α that is marked by H3K27ac in nonbasal breast invasive carcinomas (BRCA), thyroid carcinoma (THCA) and uterine corpus endometrial carcinoma (UCEC), but with increased looping to the ESR1 promoter in UCEC, which correlates with higher ESR1 expression (Extended Data Fig. 4g).