Consistent with prior results from chromatin accessibility profiling, cancer-type-specific peaks and loops identified by HiChIP were enriched for relevant transcription factor (TF) motifs, including p63 in squamous cancers (ESCC and lung squamous cell carcinoma (LUSC)) and androgen response elements in prostate adenocarcinomas (PRAD; Extended Data Fig. 4c,d). Here, TF is linked to esophageal squamous cell carcinoma.