The 3D chromatin landscape across cancer types suggested the following three classifications of enhancer usage: (1) static enhancer usage, exemplified by NRAS (encoding neuroblastoma RAS viral oncogene homolog); (2) selective enhancer connectivity in one cancer type, such as EGFR (encoding epidermal growth factor receptor) in glioblastoma; and (3) highly dynamic patterns of enhancer contacts, including MYC (encoding MYC proto-oncogene, bHLH transcription factor; Fig. 1d, Extended Data Fig. 5a,b and Supplementary Table 4). Here, EGFR is linked to cancer.