MYC and cancer: We assessed one-dimensional (1D) H3K27ac ChIP enrichment detected by HiChIP and observed H3K27ac enrichment either at regulatory elements located 5′ of MYC in cancer types such as colon adenocarcinoma (COAD) or at 3′ regulatory elements as in liver hepatocellular carcinoma (LIHC; Fig. 1d,e).