Considering the prevalence of eIF1A gain of function mutations in certain cancer cell types, including uveal melanoma and ovarian carcinoma (Etemadmoghadam et al, 2017; Ewens et al, 2014; Karunamurthy et al, 2016), and the essentiality of eIF1A for cell proliferation (Sehrawat et al, 2019), we first assessed the ability of 1Ais to influence the viability and proliferation of an ovarian cancer cell line, OVCAR8. Here, EIF1 is linked to uveal melanoma.