Co-transfection and co-infection experiments showed that both YTHDC1 and its W378A mutant, but not the YTHDC1 ∆IDR variant, were able to prevent ARIH2-induced degradation of PPARγ in HEK293T cells (Fig. 8A), primary brown adipocytes (Fig. 8B), and primary white adipocytes (Appendix Fig. S8A). The gene discussed is PPARG; the disease is infection.