Notably, we discovered AldoB, which is physiologically barely expressed in adult, mature beta cells, to be among the most upregulated genes and proteins in islets of subjects with type 2 diabetes, with its levels being tightly correlated with those of glycosylated hemoglobin (HbA1c), the most reliable biomarker of hyperglycemia (Gerst et al, 2018; Solimena et al, 2018; Wigger et al, 2021). This evidence concerns the gene ALDOB and type 2 diabetes mellitus.