CASR and secondary hyperparathyroidism: For instance, strontium-induced osteoclast apoptosis activates the anabolic Wnt pathway and promotes Akt phosphorylation (p-AKT) downstream of CaSR in osteoblasts.159 Additionally, it encourages osteoblastgenesis while inhibiting osteoclastogenesis by blocking NF-κB activation.160 Cinacalcet, an FDA-approved small molecule PAM of CaSR, is used for the treatment of primary and secondary hyperparathyroidism.