SH3BP4 and type 2 diabetes mellitus: To validate the positive correlation between cg19998400 methylation and SH3BP4 expression, we used data from both the Scandinavian T2D-discordant MZ twin cohort (n = 12 MZ pairs) and TwinsUK22 (n = 79 MZ pairs, 111 DZ pairs, and 154 singletons) (Supplementary Table 8).