More importantly, the correlations between the expression of IGF2BP3 and RA progression markers was assessed using the GSE89408 dataset, which indicated that IGF2BP3 was positively correlated with MMP1, MMP3, SPP1, IL-1β, M1 proportion, CD80, CD86 and IL-6 (Fig. S2b–i). This evidence concerns the gene MMP3 and rheumatoid arthritis.