S100A8 and rheumatoid arthritis: Lower levels of MALAT1 promote the ubiquitination-mediated degradation of S100A8/S100A9, thereby impeding p38/mitogen-activated protein kinase phosphorylation and macrophage-mediated inflammation.40 Altogether, our findings lay a strong foundation for a new mechanism by which IGF2BP3 regulates synovial cell proliferation and inflammatory activation in patients with RA.