TNF and rheumatoid arthritis: In addition, IL-6, TNF-α, IL-17 and MMP3, which are key components of phenotypic changes observed in RA lesions, were selected to evaluated the inflammatory level of RA-FLS.23 We found siIGF2BP3 reduced the mRNA expression levels of inflammatory cytokines, including TNF-α, IL-17 and MMP3 (Fig. 2d); and siIGF2BP3 decreased IL-6 secretion (Fig. 2e).