Compared with those in WT arthritis mice, the expression levels of iNOS, p62 and p-S6K was lower in the synovium of IGF2BP3-KO arthritic mice, which further indicated IGF2BP3 knockdown alleviated RA progression by inhibiting mTORC1 activation and autophagy (Fig. S9l, m). Here, NOS2 is linked to arthritic joint disease.