Yu Kuang et al. also reported that ALKBH5 mediates the m6A modification of the JARID2 mRNA and collaborates with IGF2BP3 to enhance its mRNA stability, thereby regulating the migration, invasion and proliferation of RA-FLS.17 In addition, we found that IGF2BP3 and RASGRF1 were closely related to M1 macrophages proportion and the levels of inflammatory markers (IL-1β, IL-6, CD80 and CD86) in the RA synovium, suggesting that IGF2BP3 and RASGRF1 are involved in the regulation of macrophage polarization. This evidence concerns the gene IL1B and rheumatoid arthritis.