IGF2BP3 is an m6A RNA-binding protein whose KH domain serves as a core domain for recognizing m6A GC sequences, which can promote mRNA stability and the translation of downstream target genes.28 Therefore, to identify potential m6A hypermethylated targets binding to IGF2BP3 in RA, we intersected hypermethylated transcripts with up-enriched transcripts of IGF2BP3 RIP-seq, resulting in a total of 228 transcripts (Fig. 4c). Here, IGF2BP3 is linked to rheumatoid arthritis.