Moreover, the arthritis severity of CIA rats injected with ALKBH5-shRNA was improved.17,18 Studies have also shown that METTL3-mediated m6A modification of ATG7 regulates the autophagy-GATA4 axis to promote degenerative changes in synovialis, degradation of articular cartilage matrix and secretion of inflammatory factors.19 At present, comprehensive data on the role of m6A -modified proteins in synovial proliferation and joint destruction in RA are lacking, and further studies are needed to clarify their exact roles in RA. This evidence concerns the gene METTL3 and rheumatoid arthritis.