TNF and rheumatoid arthritis: To simulate the chronic inflammation and tissue destruction environment in RA, we applied 10 ng/mL TNF-α to RA-FLS.21,22 We found that the mRNA and protein expression levels of IGF2BP3 were significantly increased after stimulation with TNF-α, whereas siIGF2BP3 inhibited the expression level of IGF2BP3 mRNA (Fig. S3c) and protein (Fig. 2a, Fig. S3d).