SPP1 and rheumatoid arthritis: More importantly, the correlations between the expression of IGF2BP3 and RA progression markers was assessed using the GSE89408 dataset, which indicated that IGF2BP3 was positively correlated with MMP1, MMP3, SPP1, IL-1β, M1 proportion, CD80, CD86 and IL-6 (Fig. S2b–i).