RASGRF1 and rheumatoid arthritis: In addition, the colocalization between RASGRF1 and iNOS (a marker of M1 macrophages) was examined in synovial tissue, which revealed the upregulation of RASGRF1 in M1 macrophages from RA patients (Fig. S6g, h) and CIA synovial tissue (Fig. S6i, j).