MAPT and Mental deterioration: Despite significant research efforts, we are currently unable to effectively address the cognitive decline associated with Alzheimer’s, which is projected to affect a staggering 150 million people by 2050.1,2 For decades, research has mainly focused on the deposition of amyloid-beta (Aβ) protein in senile plaques outside the neurons and the formation of neurofibrillary tangles (NFT) composed of hyperphosphorylated Tau (p-Tau) protein inside the neurons.