AIF1 and Alzheimer disease: Administration of bEVs derived from SPF housed WT or AppNL-G-F AD mice to GF housed AppNL-G-F AD mice resulted in limited effects, namely a non-significant decrease in number and ramification of IBA1+ microglial cells compared to GF housed AppNL-G-F AD mice that received bEVs from GF housed AppNL-G-F AD mice (Figure 7(a–d)).