Moreover, we found that the volume of PSD-95-positive puncta within CD68+ phagosomes and IBA1+ microglia is decreased in GF housed AppNL-G-F AD mice compared to SPF housed AppNL-G-F AD mice, indicating an increased phagocytosis of synapses by microglia (Figure 3(e,f)). The gene discussed is DLG4; the disease is Alzheimer disease.