Diabetes mellitus (DM) is a condition in which the body either fails to produce sufficient insulin or does not respond to it effectively, leading to elevated blood sugar (glucose) levels.[1] According to the International Diabetes Federation Diabetes Atlas (2021), 10.5% of adults aged 20 to 79 have diabetes, with nearly half of them unaware that they have the condition.[2] Managing diabetes is challenging and involves optimizing existing treatments to maintain glycemic, blood pressure, and lipid control while minimizing complications. This evidence concerns the gene INS and diabetes mellitus.