Intriguingly, we discovered that the top 10 key targets, including TP53, EGFR, JAK2, STAT3, MAPK8, mitogen-activated protein kinase 1, mitogen-activated protein kinase 3 (MAPK3), SRC, transcription factor Jun (JUN), and RAC-alpha serine/threonine-protein kinase (AKT1) were found in the top 3 central gene clusters, which consolidated their essential roles in the treatment of NSCLC by CR. This evidence concerns the gene MAPK3 and non-small cell lung carcinoma.