It is shown that the hypomethylation effect of WIF-1 (a tumor suppressor gene) treated with demethoxycurcumin is stronger than that treated with curcumin in A549, SPC-A-1, and H460 cell lines.[27] Apart from diarylheptanoids, sesquiterpenes are another large group of secondary metabolites in CR with various evident bioactivities.[28,29] Our study suggested that reynosin, a sesquiterpene lactone, had high affinity to the critical targets of NSCLC, including EGFR, SRC, JAK2, and MAPK8, suggesting its therapeutic value in treating NSCLC. Here, MAPK8 is linked to non-small cell lung carcinoma.