Moreover, such an environment promotes angiogenesis, facilitating the formation of new blood vessels that supply the growing tumor with essential nutrients and oxygen, thereby supporting tumor expansion and enhancing its metastatic potential.[26] In addition, the oxidative stress and DNA damage associated with chronic inflammation can lead to genetic mutations, further driving HER2-positive breast cancer progression and metastasis.[27]. The gene discussed is ERBB2; the disease is breast carcinoma.