The diabetes has become a significant public health issue, and the global burden of disease study shows that there are 529 million diabetic patients in the world in 2021, and the number is expected to rise to 1.31 billion by 2050.[1] The estimated number of individuals affected by diabetes in China reached 140.8 million in 2021, with projections from the International Diabetes Federation indicating an increase to 174.4 million by 2045.[2] Long-term insulin therapy is essential in patients with diabetes. This evidence concerns the gene INS and diabetes mellitus.