While this observation diverges from the typical pattern reported in many non-African populations, where ε2 is often underrepresented among AD cases, it highlights the complex and potentially population-specific role of APOE ε2 in AD pathogenesis.[9,30] Despite its modest frequency difference, the presence of ε2 did not show a statistically significant protective effect in our logistic regression analysis, possibly due to the limited sample size or the influence of other confounding factors, such as genetic admixture, lifestyle differences, or comorbid health conditions. Here, APOE is linked to Alzheimer disease.