MAPT and Alzheimer disease: APOE4 not only influences the deposition and aggregation of Aβ but also exacerbates tau pathology and associated neurodegeneration.[11,12] Moreover, APOE4 has been implicated in the dysfunction of several critical brain processes, including synaptic integrity, glucose metabolism, and cerebrovascular function.[13] The multifaceted involvement of APOE in AD pathogenesis makes it a pivotal target for therapeutic strategies aimed at delaying or mitigating AD progression.