For example, APOE4 interacts with receptors such as LDL receptor-related protein 1 (LRP1) and very-low-density lipoprotein (VLDL) receptors more strongly than APOE2 or APOE3, leading to altered lipid uptake and impaired clearance of amyloid-beta.[14] Conversely, APOE2 is associated with enhanced receptor-mediated lipid transport and neuroprotection.[9] APOE4’s interaction with LDL receptor-related proteins, such as LRP1 and VLDL, alters lipid transport and distribution, potentially exacerbating AD-related processes. This evidence concerns the gene LRP1 and Alzheimer disease.