By activating this receptor, cxcl13 serves a crucial function in modulating immune responses by guiding B and T cell homing.[28] Studies have revealed that plasma cxcl13 concentrations are closely correlated with the progression and severity of IPF, making it a potential biomarker for predicting disease trajectory,[29] this is consistent with the results of our study. The gene discussed is CXCL13; the disease is idiopathic pulmonary fibrosis.