For example, MHC class I polypeptide-related sequence B_A (MICB_MICA), tyrosine-protein kinase receptor tie-1 (TIE-1) and granulocyte colony-stimulating factor (G-CSF) would increase 8%, 27% and 70% COPD risk (MICB_MICA: OR, 1.08; 95% CI, 1.05–1.10; PFDR = 2.53 × 10−5; TIE-1: OR, 1.27; 95% CI, 1.13– 1.43; PFDR = .012 and G-CSF: OR, 1.70; 95% CI, 1.28–2.27; PFDR = .027). This evidence concerns the gene TIE1 and chronic obstructive pulmonary disease.