Alpha-1-antitrypsin and Drebrin were negatively associated with the later-onset COPD risk, while C-X-C motif chemokine 17 showed a positive causal association (Fig. 2C and Tables S4, Supplemental Digital Content, https://links.lww.com/MD/O878; S5, Supplemental Digital Content, https://links.lww.com/MD/O876; S6, Supplemental Digital Content, https://links.lww.com/MD/O877). This evidence concerns the gene DBN1 and chronic obstructive pulmonary disease.