MHC class I polypeptide-related sequence B_A (MICB_MICA) and tyrosine-protein kinase receptor tie-1 (TIE-1) would increase 8% and 27% COPD risk (MICB_MICA: odds ratios [OR], 1.08; 95% CI, 1.05–1.10; PFDR = 2.53 × 10−5; TIE-1: OR, 1.27; 95% CI, 1.13–1.43; PFDR = .012). This evidence concerns the gene TIE1 and chronic obstructive pulmonary disease.