DAG1 is laminin-binding protein, consisting of 2 subunits, α-DG and β-DG.[59] It plays a key role in skeletal muscle stabilization and also plays a unique role in processes such as cancer progression and cell signaling.[59] An animal experiment showed that ROS-induced oxidative stress downregulated β-DG levels, which is beneficial for the progression of hypertension. This evidence concerns the gene DAG1 and hypertensive disorder.