NFKB1 and Alzheimer disease: A study has suggested that, similar to androgens, prolactin also influences sebaceous gland function, thereby playing a role in the pathogenesis of AD.[62] Cancer-related pathways, such as Wnt/β-catenin, NF-κB, and PI3K/AKT, although mainly related to the occurrence and development of tumors, have been found in recent years to also play an important role in the pathogenesis of AD.