A study has suggested that, similar to androgens, prolactin also influences sebaceous gland function, thereby playing a role in the pathogenesis of AD.[62] Cancer-related pathways, such as Wnt/β-catenin, NF-κB, and PI3K/AKT, although mainly related to the occurrence and development of tumors, have been found in recent years to also play an important role in the pathogenesis of AD. The gene discussed is PIK3CA; the disease is Alzheimer disease.