Numerous studies have elucidated that uPA promotes cell migration and the spread of prostate cancer.[26–28] In this study, MR analysis demonstrated that uPA is a risk factor for prostatitis, a condition considered to be a risk factor for prostate cancer.[29] Guo et al[30] discovered that uPA-activated plasminogen can activate the STAT3 protein. Here, PLAU is linked to male reproductive organ cancer.