The MR results revealed that Interleukin-10 receptor A (IL-10RA), Natural Killer Cell Receptor 2B4 (CD244), and urokinase-type plasminogen activator (uPA) were identified as risk factors for prostatitis (IVWIL-10RA: OR = 1.242, 95% CI: 1.043–1.478, P = .015; IVWCD244: OR = 1.143, 95% CI: 1.002–1.305, P = .047; IVWuPA: OR = 1.141, 95% CI: 1.009–1.290, P = .035). The gene discussed is PLAU; the disease is prostatitis.