The IVW analysis results for IL-10RA (IVWIL-10RA: OR = 1.242, 95% CI: 1.043–1.478, P = .015), CD244 (IVWCD244: OR = 1.143, 95% CI: 1.002–1.305, P = .047), and uPA (IVWuPA: OR = 1.141, 95% CI: 1.009–1.290, P = .035) indicated positive associations with the risk of prostatitis. The gene discussed is PLAU; the disease is prostatitis.