Moreover, reverse MR analysis results indicate that prostatitis decreases plasma levels of chemokine (C-C motif) ligand 23 (CCL23), IL-5, and TNF-related activation-induced cytokine (TRANCE) (IVWCCL23: OR = 0.949, 95% CI: 0.906–0.993, P = .025; IVWIL-5: OR = 0.938, 95% CI: 0.890–0.988, P = .016; IVWTRANCE: OR = 0.947, 95% CI: 0.905–0.992, P = .021). This evidence concerns the gene IL5 and male reproductive organ cancer.