In recent years, genetic variants, including Epiregulin (EREG),4 Toll-Like Receptor-2 (TLR2)5 and Nuclear Factor-Erythroid-2 (NF-E2)-related Factor-2 (Nrf2),6 have been demonstrated to be associated with TB susceptibility, but their roles in the incidence of TB are conflicting. The gene discussed is EREG; the disease is tuberculosis.