Comprising 60–80% of all BCCs, nodular BCC appears as pearly or translucent papules or nodules with rolled borders and telangiectasias, most commonly found on the face and neck.[3,15,16] Classically, nodular BCC (Figs 1A–1C) presents as large tumor nests comprised of basophilic-staining proliferating cells with peripheral palisading.[3] Mitoses, apoptosis, intra and peritumoral mucin, clefting, and stromal retraction away from the tumor nodules are also characteristic.[17]. Here, MUC5AC is linked to skin basal cell carcinoma.