BCC occurrence in the general population is a result of constitutive activation of the hedgehog intracellular signaling pathway, commonly associated with inactivating mutations of patched homolog 1 (PTCH1) and activating mutations of smoothened homolog (SMOm), followed by UV-specific defects in the p53 tumor suppressor gene and loss-of-function mutations in suppressor of fused homolog (SUFU). Here, SUFU is linked to skin basal cell carcinoma.