With ZC3H18 upregulated in EBV+ DLBCLs and tumor cell lines compared to EBV- lymphomas and cancer lines (Fig 1), we also depleted STAT3 in BJAB cells, which are EBV-, and found that MYC transcripts were downregulated; in contrast, however, ZC3H18 transcripts were not, supporting an EBNA1-dependent mechanism in upregulation of ZC3H18 selectively in EBV+ tumors (Fig 7G). Here, ZC3H18 is linked to cancer.