STAT3 and breast cancer: While these findings echo the effects of LLL12B on the STAT3 signaling pathway in medulloblastoma and breast cancer models [29,36,37] and APTO-253’s effects on MYC-driven proliferation of acute myelogenous leukemia, chronic lymphocytic leukemia, and myelodysplastic syndromes [38], the results from Fig 2 also suggest ZC3H18-mediated effects; we have previously shown that ZC3H18 contributes to DNA replication in EBV-transformed cells.