MYC and Burkitt lymphoma: Depletion of ZC3H18 did not demonstrate a near total loss of IKBα phosphorylation but instead, showed a 30–40% reduction in both total and phosphorylated IKBα with both shRNAs (Fig 10B), supporting previous observations that to avoid apoptosis in these high MYC expressing cells, NF-κB signaling is suppressed in BL cells [40].