Impaired degradation of lysosomes, compromised clearance of autophagosomes through lysosomes, and decreased mitochondrial respiratory capacity have all been observed in a neuroblastoma cell model with TMEM175 knockout, which further demonstrated an impaired ability to effectively clear phosphorylated α-synuclein fibrils, which are commonly observed in individuals with Parkinson's [74]. This evidence concerns the gene TMEM175 and Parkinson disease.