Given that AVP contributes to water reabsorption from primitive urine in the kidneys [17], and that a reduction in AVP expression is known to induce polyuria and polydipsia in mice [18,19], these results suggest that AVP-Cre; nCTG mice show reduced AVP secretion, likely because of decreased AVP expression in the PVH (Fig 2D) and possibly other brain regions. Here, AVP is linked to Polydipsia.