Although to date there have been no studies that have specifically examined the efficacy of Ab 28 042 in the treatment of T‐ALL, we believe this could represent a promising therapeutic strategy, given that the NOTCH3/JAGGED1 auto‐sustaining loop has been reported to play a role in the development and progression of NOTCH‐dependent T‐ALL [21]. Here, NOTCH3 is linked to acute lymphoblastic leukemia.