In an unadjusted analysis of all NGS analyte results combined, non-Hispanic White veterans were significantly more likely to harbor alterations in AKT/PI3K pathway genes (965 [29.9%] vs 355 [19.9%]; P < .001), AR signaling axis genes (1429 [44.2%] vs 616 [34.5%]; P < .001), DNA repair genes (709 [21.9%] vs 304 [17.0%]; P < .001), prostate cancer–specific PARPi targets (802 [24.8%] vs 394 [22.1%]; P = .03), and tumor suppressor genes (1655 [51.5%] vs 682 [38.2%]; P < .001) (eFigure 2A and eTable 4 in Supplement 1). This evidence concerns the gene AKT1 and Familial prostate cancer.