Undertaking a genome wide association study (GWAS) using the AxiomTM Precision Medicine Diversity Array on 157 FECD cases and 309 controls, followed by pathway enrichment analysis, we were able to confirm the significance of the TCF4 locus (rs613872, p = 8.0 × 10− 23, OR = 8.60, h2 = 0.72) and identified a range of novel variants. This evidence concerns the gene TCF4 and Fuchs endothelial corneal dystrophy.