In accordance with our results, a previous Japanese study [15] that involved 22 patients with T1DM with mean (± SD) age of 14.2 ± 4.2 years and 16 age-, sex- and sex hormone-matched healthy controls, where they found significantly elevated serum sclerostin levels in patients with T1DM than in controls, without significant differences between genders. This evidence concerns the gene SOST and type 1 diabetes mellitus.