The ROC analysis demonstrates that both serum sclerostin and CIMT are highly accurate markers for detecting DN in children and adolescents with T1DM, where it identified an optimal cut-off value of 60.01 ng/mL for serum sclerostin (AUC = 0.986, sensitivity = 88%, and specificity = 100%) and a cut-off value of 0.3 mm for CIMT (AUC = 0.998, sensitivity = 96%, and specificity = 100%) (Fig. 4). This evidence concerns the gene SOST and type 1 diabetes mellitus.