The role of Lrrk2 in PD pathophysiology remains unclear (Singh et al., 2019), and Lrrk2 mutations are often proposed as being an indirect source of dysfunction for the DA system, such as through its high expression in glial or striatal cells (Chen et al., 2020; Choi et al., 2015; Parisiadou et al., 2014; Cook et al., 2017; West et al., 2014). The gene discussed is LRRK2; the disease is Parkinson disease.