The Sox6Tafa1 SNc subtype was of particular interest to us given recent results showing that Anxa1 + ventral tier SNc neuronal activity is selectively correlated with acceleration in mice running on a treadmill, leading to the hypothesis that degeneration of these neurons may contribute to motor deficits seen in PD (Azcorra et al., 2023). The gene discussed is ANXA1; the disease is Parkinson disease.