WWTR1 and breast cancer: Indeed, studies in melanoma cells have shown that YAP/TAZ upregulation which promotes drug resistance is caused by shape changes.22,24,40,41 Moreover, a number of recent studies have shown that EMT in breast cancer, which is characterized by morphological changes and increased invasive capabilities, also leads to drug resistant cells.131 Thus, shape changes may be causal to many aspects of TNBC, and suggests that therapeutic intervention could occur by preventing cells from altering their shape.